Microenvironment and Radiation Therapy

Microenvironment and Radiation Therapy

Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia. The first approach to overcome tumor hypoxia was to improve tumor oxygenation by increasing oxygen delivery and a subsequent approach was the use of radiosensitizers in combination with radiation therapy. Clinical use of some of ...

CD47 in the tumor microenvironment limits cooperation between anti-tumor T cell immunity and radiation therapy

Microenvironment and Immunology TGFb Is a Master Regulator of Radiation Therapy- Induced Antitumor Immunity

T cells directed to endogenous tumor antigens are powerful mediators of tumor regression. Recent immunotherapy advances have identified effective interventions to unleash tumor-specific T-cell activity in patients who naturally develop them. Eliciting T-cell responses to a patient's individual tumor remains a major challenge. Radiation therapy can induce immune responses to model antigens expre...

3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk

Background: Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques are used for the treatment of patients with laryngeal cancer. Objective: This study aimed to investigate the effects of these 2 treatment techniques on the planning target volume (PTV) (laryngeal cancer), dose homogeneity, dose of organs at...

Microenvironment Damage Induced Therapy Resistance

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT The armamentarium of therapeutics used to treat cancer patients relies heavily on ionizing radiation and chemotherapeutic drugs that severely damage DNA. The responses of tumor cells to these treatments is heavily influenced by their environment: physical contacts with structural eleme...